Caution in the Use of a 100 Mg Dose of Racemic Mephenytoin for Phenotyping Southeastern Oriental Subjects

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1992 Jun 1

PMID 1389943

Citations 4

Authors

R Setiabudy

K Chiba

M Kusaka

T Ishizaki

Affiliations

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Citing Articles

Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.

Klaassen T, Jetter A, Tomalik-Scharte D, Kasel D, Kirchheiner J, Jaehde U Eur J Clin Pharmacol. 2007; 64(4):387-98.

PMID: 18071681 DOI: 10.1007/s00228-007-0416-z.

Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events.

Tamminga W, Wemer J, Oosterhuis B, Wieling J, Touw D, de Zeeuw R Br J Clin Pharmacol. 2001; 51(5):471-4.

PMID: 11422005 PMC: 2014478. DOI: 10.1046/j.1365-2125.2001.01331.x.

Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.

Brosen K, Skjelbo E, Flachs H Br J Clin Pharmacol. 1993; 36(2):105-8.

PMID: 8398577 PMC: 1364572. DOI: 10.1111/j.1365-2125.1993.tb04204.x.

Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.

Setiabudy R, Kusaka M, Chiba K, Darmansjah I, Ishizaki T Br J Clin Pharmacol. 1995; 39(3):297-303.

PMID: 7619672 PMC: 1365007. DOI: 10.1111/j.1365-2125.1995.tb04452.x.

References

Wilkinson G, Guengerich F, Branch R . Genetic polymorphism of S-mephenytoin hydroxylation. Pharmacol Ther. 1989; 43(1):53-76. DOI: 10.1016/0163-7258(89)90047-8. View

Horai Y, Nakano M, Ishizaki T, Ishikawa K, Zhou H, Zhou B . Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese. Clin Pharmacol Ther. 1989; 46(2):198-207. DOI: 10.1038/clpt.1989.126. View

Jurima M, Inaba T, KADAR D, KALOW W . Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians. Br J Clin Pharmacol. 1985; 19(4):483-7. PMC: 1463809. DOI: 10.1111/j.1365-2125.1985.tb02673.x. View

Wedlund P, Aslanian W, Jacqz E, McALLISTER C, Branch R, Wilkinson G . Phenotypic differences in mephenytoin pharmacokinetics in normal subjects. J Pharmacol Exp Ther. 1985; 234(3):662-9. View

Kupfer A, Preisig R . Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man. Eur J Clin Pharmacol. 1984; 26(6):753-9. DOI: 10.1007/BF00541938. View