Genetic Polymorphism of Mephenytoin P(4')-hydroxylation: Difference Between Orientals and Caucasians

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1985 Apr 1

PMID 3994895

Citations 29

Authors

M Jurima

T Inaba

D KADAR

W KALOW

Affiliations

Soon will be listed here.

Abstract

The genetically controlled mephenytoin p(4')-hydroxylation capacity was determined in 118 Caucasians and 70 Orientals. After an oral dose of 50 or 100 mg of racemic mephenytoin, the amount of p(4')-hydroxymephenytoin in 24 h urine was measured by gas chromatography. Bimodal distribution was found with 9/70 (13%) Orientals and 5/118 (4%) Caucasians demonstrating deficient p(4')-hydroxylation. The statistically significant difference between Orientals and Caucasians (P less than 0.05) was accounted for by the high incidence of poor metabolizers among the Japanese subjects, 7/31 (23%). The frequency among Chinese subjects, 2/39 (5%), was similar to the frequency among Caucasians.

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