Estradiol Reduces Incorporation of Radioactive Sulfate into Cartilage and Aortas of Rats

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1960 Jul 1

PMID 13738006

Citations 8

Authors

R E PRIEST

R M KOPLITZ

E P BENDITT

Affiliations

Soon will be listed here.

Abstract

Estradiol in large amounts reduces the incorporation of radioactive sulfate into cartilage and aortas of rats. This reduction becomes apparent within 3 days for cartilage and 3 weeks for aorta. The effect is not mediated through suppression of testosterone secretion and the hypophysis is not necessary for the effect to be demonstrated. The thoracic segment of aortas from normal rats incorporates more sulfate than does the abdominal segment and this difference is reduced following the administration of estradiol.

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Inhibition of synthesis of sulfated mucopolysaccharides by estradiol.

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Selective inhibition of proteoglycan and hyaluronate synthesis in chondrocyte cultures by cyclofenil diphenol, a non-steroidal weak oestrogen.

Mason R, Lineham J, Phillipson M, Black C Biochem J. 1984; 223(2):401-12.

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