Integrin Expression by Human Articular Chondrocytes

Overview

Journal Br J Rheumatol

Publisher Oxford University Press

Specialty Rheumatology

Date 1992 Apr 1

PMID 1372838

Citations 28

Authors

D M Salter

D E Hughes

R Simpson

D L Gardner

Affiliations

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Abstract

Expression of integrins, a family of cell adhesion proteins, by human articular cartilage chondrocytes in vivo has been studied by immunohistological techniques using cryostat sections and a panel of anti-integrin monoclonal antibodies. Chondrocytes strongly expressed beta 1 and alpha 5 integrin subunits, known to form the classical fibronectin receptor, VLA-5, strongly. alpha 1 was expressed more weakly and variably; alpha 3 was expressed by occasional cells only. Chondrocytes did not express beta 2, beta 3 or other integrin alpha subunits tested.

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