Proline-specific Aminopeptidases: Potential Role in Bradykinin Degradation

Overview

Journal Agents Actions Suppl

Specialty Pharmacology

Date 1992 Jan 1

PMID 1361094

Citations 3

Authors

G Vanhoof

I De Meester

D Hendriks

F Goossens

M VAN SANDE

S Scharpe

A YARON

Affiliations

Soon will be listed here.

Abstract

The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5). Additional evidence is provided for the hypothesis that these proline-specific aminopeptidases play an essential role in the degradation of peptides containing an N-terminal Xaa-Pro sequence.

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