The Nature of Antigen-antibody Complexes Formed in Rabbits During an Immune Response to Bovine Serum Albumin

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1958 May 1

PMID 13525577

Citations 5

Authors

W O Weigle

Affiliations

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Abstract

The immune elimination of soluble BSA, following an intravenous injection, is accompanied by the appearance of circulating antigen-antibody complexes. The pattern of the appearance of circulating antigen-antibody complexes and the immune elimination of antigen probably depends on the amount of antigen injected, the rate of antibody synthesis, and perhaps, the quality of antibody produced. There is no relationship between the I* antigen-antibody complexes detected during the immune response in rabbits by ammonium sulfate precipitation and the material precipitated from immune sera as a result of treatment with alkali. Alkali-precipitable material present in the serum of rabbits at a time when I* antigen is also present contain at most only traces of the antigen.

Citing Articles

The fate of some alum-precipitated proteins after intramuscular injection.

Hawkins J Immunology. 1963; 6:179-88.

PMID: 13953216 PMC: 1423232.

The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins.

Weigle W J Exp Med. 1961; 114:111-25.

PMID: 13783813 PMC: 2137445. DOI: 10.1084/jem.114.1.111.

Elimination of 131-I-labelled protein antigens from the circulation of the mouse.

Dresser D Immunology. 1960; 3:289-95.

PMID: 13724355 PMC: 1424018.

The cutaneous reaction to soluble antigen-antibody complexes; a comparison with the Arthus phenomenon.

Cochrane C, Weigle W J Exp Med. 1958; 108(5):591-604.

PMID: 13587844 PMC: 2136907. DOI: 10.1084/jem.108.5.591.

The coexistence of antibody with antigen during immunological paralysis to BSA.

Day J, Farr R Immunology. 1966; 11(6):571-88.

PMID: 5954774 PMC: 1423813.

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