An Analysis of Extracellular Potentials from Single Neurons in the Lateral Geniculate Nucleus of the Cat

Overview

Journal J Gen Physiol

Specialty Physiology

Date 1958 Jan 20

PMID 13491821

Citations 27

Authors

W H FREYGANG Jr

Affiliations

Soon will be listed here.

Abstract

The lateral geniculate nucleus of the cat was explored with micropipettes having submicroscopic tips. The only reliably recorded intracellular activity was from axons. Following orthodromic stimulation, the potentials recorded by the extracellular electrodes registered the net flow of current across the soma-dendritic membrane of the principal cell bodies. The current has three phases of flow away from the soma-dendritic membrane followed by a flow of current toward this membrane. The first component is ascribed to synaptic activity. Subsequent components are ascribed to the activity of the initial segment of the axon and a limited area of high threshold membrane on the soma. The evidence is interpreted as suggesting that most of the soma-dendritic membrane is excited synaptically to produce a postsynaptic potential, but is not excited electrically and does not produce a propagating spike.

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References

PHILLIPS C . Cortical motor threshold and the thresholds and distribution of excited Betz cells in the cat. Q J Exp Physiol Cogn Med Sci. 1956; 41(1):70-84. DOI: 10.1113/expphysiol.1956.sp001164. View

Frank K, FUORTES M . Potentials recorded from the spinal cord with microelectrodes. J Physiol. 1955; 130(3):625-54. PMC: 1363403. DOI: 10.1113/jphysiol.1955.sp005432. View

Grundfest H . Electrical inexcitability of synapses and some consequences in the central nervous system. Physiol Rev. 1957; 37(3):337-61. DOI: 10.1152/physrev.1957.37.3.337. View

Bishop P, JEREMY D, McLeod J . Phenomenon of repetitive firing in lateral geniculate of cat. J Neurophysiol. 1953; 16(4):437-47. DOI: 10.1152/jn.1953.16.4.437. View

Rose J, MOUNTCASTLE V . Activity of single neurons in the tactile thalamic region of the cat in response to a transient peripheral stimulus. Bull Johns Hopkins Hosp. 1954; 94(5):238-82. View

Glees P, Le Gros Clark W . The termination of optic fibres in the lateral geniculate body of the monkey. J Anat. 1941; 75(Pt 3):295-308.3. PMC: 1252642. View

Tasaki I . Initiation and abolition of the action potential of a single node of Ranvier. J Gen Physiol. 1956; 39(3):377-95. PMC: 2147540. DOI: 10.1085/jgp.39.3.377. View

Bishop P . Synaptic transmission; an analysis of the electrical activity of the lateral geniculate nucleus in the cat after optic nerve stimulation. Proc R Soc Lond B Biol Sci. 1953; 141(904):362-92. DOI: 10.1098/rspb.1953.0048. View

FATT P, Katz B . Spontaneous subthreshold activity at motor nerve endings. J Physiol. 1952; 117(1):109-28. PMC: 1392564. View

10.

Chang H . Cortical neurons with particular reference to the apical dendrites. Cold Spring Harb Symp Quant Biol. 1952; 17:189-202. DOI: 10.1101/sqb.1952.017.01.019. View

11.

Frank K, FUORTES M . Stimulation of spinal motoneurones with intracellular electrodes. J Physiol. 1956; 134(2):451-70. PMC: 1359217. DOI: 10.1113/jphysiol.1956.sp005657. View

12.

BISHOP G, CLARE M . Organization and distribution of fibers in the optic tract of the cat. J Comp Neurol. 1955; 103(2):269-304. DOI: 10.1002/cne.901030204. View

13.

Bishop P, JEREMY D, Lance J . The optic nerve; properties of a central tract. J Physiol. 1953; 121(2):415-32. PMC: 1366084. DOI: 10.1113/jphysiol.1953.sp004955. View

14.

GRANIT R, PHILLIPS C . Excitatory and inhibitory processes acting upon individual Purkinje cells of the cerebellum in cats. J Physiol. 1956; 133(3):520-47. PMC: 1359117. DOI: 10.1113/jphysiol.1956.sp005606. View

15.

COOMBS J, ECCLES J, FATT P . The inhibitory suppression of reflex discharges from motoneurones. J Physiol. 1955; 130(2):396-413. PMC: 1363417. DOI: 10.1113/jphysiol.1955.sp005414. View

16.

COOMBS J, ECCLES J, FATT P . Excitatory synaptic action in motoneurones. J Physiol. 1955; 130(2):374-95. PMC: 1363416. DOI: 10.1113/jphysiol.1955.sp005413. View

17.

Grundfest H, Purpura D . Nature of dendritic potentials and synaptic mechanisms in cerebral cortex of cat. J Neurophysiol. 1956; 19(6):573-95. DOI: 10.1152/jn.1956.19.6.573. View

18.

Tasaki I, POLLEY E, Orrego F . Action potentials from individual elements in cat geniculate and striate cortex. J Neurophysiol. 1954; 17(5):454-74. DOI: 10.1152/jn.1954.17.5.454. View

19.

Glees P . The termination of optic fibres in the lateral geniculate body of the cat. J Anat. 1941; 75(Pt 4):434-440.1. PMC: 1252630. View

20.

FATT P . Electric potentials occurring around a neurone during its antidromic activation. J Neurophysiol. 1957; 20(1):27-60. DOI: 10.1152/jn.1957.20.1.27. View