The Oxidation of Cystamine and Homocystamine by Mammalian Enzymes

Overview

Journal Br J Pharmacol Chemother

Specialty Pharmacology

Date 1957 Dec 1

PMID 13489183

Citations 2

Authors

B Bergeret

H BLASCHKO

Affiliations

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Abstract

The oxidative deamination of cystamine and homocystamine by mammalian oxidases has been studied. The histaminase of pig kidney oxidizes homocystamine much more slowly than cystamine. The amine oxidase of mammalian liver (guinea-pig, rabbit) oxidizes homocystamine more rapidly than cystamine. Both amines are oxidized by plasma (or serum) of ruminants (ox, sheep, goat) and of the horse. In the enzymatic oxidation of homocystamine both aminogroups are removed; there is no evidence that a ring compound analogous to cystaldimine is accumulating.

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References

Hirsch J . Spermine oxidase: an amine oxidase with specificity for spermine and spermidine. J Exp Med. 1953; 97(3):345-55. PMC: 2136271. DOI: 10.1084/jem.97.3.345. View

TABOR C, Tabor H, Rosenthal S . Purification of amine oxidase from beef plasma. J Biol Chem. 1954; 208(2):645-61. View

Cavallini D, De Marco C, MONDOVI B . The oxidation of cystamine and other sulfur-diamines by diamine-oxidase preparations. Experientia. 1956; 12(10):377-9. DOI: 10.1007/BF02157276. View

Barlow R, BLASCHKO H, HIMMS J, Trendelenburg U . Observations on omega-amino-polymethylene trimethylammonium compounds. Br J Pharmacol Chemother. 1955; 10(1):116-23. PMC: 1509481. DOI: 10.1111/j.1476-5381.1955.tb00069.x. View

BLASCHKO H, Hawkins J . Enzymic oxidation of aliphatic diamines. Br J Pharmacol Chemother. 1950; 5(4):625-32. PMC: 1509999. DOI: 10.1111/j.1476-5381.1950.tb00612.x. View