Expression of the CD4 Gene Requires a Myb Transcription Factor

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1992 Apr 1

PMID 1347906

Citations 46

Authors

G Siu

A L Wurster

J S Lipsick

S M Hedrick

Affiliations

Soon will be listed here.

Abstract

We have analyzed the control of developmental expression of the CD4 gene, which encodes an important recognition molecule and differentiation antigen on T cells. We have determined that the CD4 promoter alone functions at high levels in the CD4+ CD8- mature T cell but not at the early CD4+ CD8+ stage of T-cell development. In addition, the CD4 promoter functions only in T lymphocytes; thus, the stage and tissue specificity of the CD4 gene is mediated in part by its promoter. We have determined that a Myb transcription factor binds to the CD4 promoter and is critical for full promoter function. Thus, Myb plays an important role in the expression of T-cell-specific developmentally regulated genes.

Citing Articles

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c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.

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