Transcription Activation by the Adenovirus E1a Protein

Overview

Journal Nature

Specialty Science

Date 1989 Mar 2

PMID 2521923

Citations 313

Authors

J W Lillie

M R Green

Affiliations

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Abstract

The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.

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