The Nucleic Acids of T2, T4, and T6 Bacteriophages

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1957 Aug 1

PMID 13449234

Citations 6

Authors

M A JESAITIS

Affiliations

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Abstract

The deoxyribonucleic acids of the wild type strains of the T(2), T(4), and T(6) bacteriophages have been shown to contain glucose as an integral part of the molecule; the amount of hexose present in each nucleic acid differs. A study of the acid degradation products of the three nucleic acids has revealed that in each instance glucose is linked to the apurinic acid component. In the case of the T(6) nucleic acid it was found that two molecules of glucose are linked to hydroxymethylcytidylic acid. The other mononucleotides contained no glucose. From the results which have been presented here, and from data presented by others, it can be concluded that the three viral nucleic acids differ in that they contain different proportions of free and glucose-substituted hydroxymethylcytidylic acids.

Citing Articles

ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. INFLUENCE OF BACTERIOPHAGE T2 ON THE SYNTHETIC PATHWAY IN HOST CELLS.

Kornberg A, Zimmerman S, Kornberg S, Josse J Proc Natl Acad Sci U S A. 1959; 45(6):772-85.

PMID: 16590443 PMC: 222636. DOI: 10.1073/pnas.45.6.772.

THE INHERITANCE OF THE PROTEIN AND NUCLEIC ACID CHARACTERISTICS OF T2 AND T6 BACTERIOPHAGE.

JESAITIS M J Exp Med. 1965; 121:133-51.

PMID: 14253480 PMC: 2137963. DOI: 10.1084/jem.121.1.133.

The inheritance of the glucose component of the phage nucleic acids.

JESAITIS M J Gen Physiol. 1961; 44:585-603.

PMID: 13789984 PMC: 2195108. DOI: 10.1085/jgp.44.3.585.

Biosynthesis of pentose in Escherichia coli. Synthesis of deoxyribose in cells infected with bacteriophage.

Wright E, Sable H, Bailey J J Bacteriol. 1961; 81:845-51.

PMID: 13786776 PMC: 314750. DOI: 10.1128/jb.81.6.845-851.1961.

The nature of colicin K from Proteus mirabilis.

JESAITIS M J Exp Med. 1970; 131(5):1016-38.

PMID: 4986216 PMC: 2138826. DOI: 10.1084/jem.131.5.1016.

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