Analysis of the UL36 Open Reading Frame Encoding the Large Tegument Protein (ICP1/2) of Herpes Simplex Virus Type 1

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1992 Dec 1

PMID 1331541

Citations 27

Authors

D S McNabb

R J Courtney

Affiliations

Soon will be listed here.

Abstract

Using peptide antisera specific for regions within the N terminus and C terminus of the predicted UL36 gene product, immunoblotting experiments were performed to demonstrate definitively that ICP1/2 is encoded by the UL36 gene. These data also suggest that both the cell- and the virion-associated forms of ICP1/2 are colinear with the complete predicted amino acid sequence of the UL36 gene. Computer-assisted analyses of the predicted amino acid sequence of the UL36 gene revealed the presence of two putative leucine zipper-type motifs and a potential ATP-binding domain. The possible functions of these consensus domains will also be discussed.

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