The Role of the Leucine Zipper in the Fos-jun Interaction

Overview

Journal Nature

Specialty Science

Date 1988 Dec 15

PMID 2974122

Citations 238

Authors

T Kouzarides

E Ziff

Affiliations

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Abstract

Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine residues stabilizes the interaction between the fos and jun proteins. We show that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat of fos contribute to the DNA-binding potential of the complex.

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