» Articles » PMID: 1325393

Breathless, a Drosophila FGF Receptor Homolog, is Essential for Migration of Tracheal and Specific Midline Glial Cells

Overview
Journal Genes Dev
Specialty Molecular Biology
Date 1992 Sep 1
PMID 1325393
Citations 138
Authors
Affiliations
Soon will be listed here.
Abstract

A Drosophila homolog of the fibroblast growth factor (FGF) receptor was isolated and structurally characterized. After EMS mutagenesis or imprecise excisions of marked P elements inserted upstream to the gene, a phenotypic series of mutations in the locus was isolated. The mutants exhibit defects in the two embryonic tissues in which the receptor is expressed: the tracheal system and the midline. The tracheal cells fail to migrate in severe mutants and remain within the tracheal pits. Hypomorphic alleles exhibit partial migration of all tracheal branches; thus, the locus was termed breathless (btl). In the midline of the mutant embryos, the posterior pair of midline glial cells begins to migrate anteriorly, but fails to reach the posterior commissure. Abnormalities in cell migration appear to be a common denominator for the btl defects in these two disparate tissues. In hypomorphic mutants the cells exhibit partial migration but follow the normal tracts, suggesting that the presence of this receptor is essential for the ability of the migrating cells to recognize external guiding cues.

Citing Articles

Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila.

Lee J, Lee K, Jang I, Nam K, Kim S, Kyung M Nat Commun. 2025; 16(1):2199.

PMID: 40038269 PMC: 11880416. DOI: 10.1038/s41467-025-57484-4.


Enhanced Age-Dependent Motor Impairment in Males of Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase.

Palmer E, Snoddy C, York P, Davis S, Hunter M, Krishnan N Biology (Basel). 2024; 13(11).

PMID: 39596808 PMC: 11591802. DOI: 10.3390/biology13110854.


A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification.

Li Y, Lu T, Dong P, Chen J, Zhao Q, Wang Y Nat Commun. 2024; 15(1):2019.

PMID: 38448482 PMC: 10917797. DOI: 10.1038/s41467-024-46455-w.


Organogenetic transcriptomes of the Drosophila embryo at single cell resolution.

Peng D, Jackson D, Palicha B, Kernfeld E, Laughner N, Shoemaker A Development. 2024; 151(2).

PMID: 38174902 PMC: 10820837. DOI: 10.1242/dev.202097.


Controlled Plasma Membrane Delivery of FGFR1 and Modulation of Signaling by a Novel Regulated Anterograde RTK Transport Pathway.

Hinsch C, Venkata J, Hsu T, Dammai V Cancers (Basel). 2023; 15(24).

PMID: 38136383 PMC: 10741464. DOI: 10.3390/cancers15245837.