Blockade of GABAB Receptors Accelerates Amygdala Kindling Development

Overview

Journal Experientia

Specialty Science

Date 1992 Aug 15

PMID 1325369

Citations 3

Authors

G Karlsson

K Klebs

T Hafner

M Schmutz

H R Olpe

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the putative role of GABAB receptors in the development of amygdala kindling in rats. The effects of the GABAB blocker CGP 35348 and the GABAB agonist baclofen on the progressive development of behavioural seizure symptoms (stages 1-5 classified by Racine) and duration of after-discharges (AD) were studied. CGP 35348 at a dose of 300 mg/kg i.p., which blocks central GABAB receptors, moderately but consistently accelerated the development of behavioural seizure symptoms. CGP 35348 had no marked effect on the duration of ADs corresponding to the different seizure stages. L-baclofen (6 mg/kg i.p.) had a dual effect on kindling development. It retarded the development of the behavioural symptoms, but increased the duration of AD. In conclusion, the results suggest that synaptically-released GABA activated GABAB receptors and thereby exerted a depressant effect on kindling development.

Citing Articles

GABA receptor attenuation of GABA currents in neurons of the mammalian central nervous system.

Shen W, Nan C, Nelson P, Ripps H, Slaughter M Physiol Rep. 2017; 5(6).

PMID: 28348006 PMC: 5371550. DOI: 10.14814/phy2.13129.

Regulating hippocampal hyperexcitability through GABAB Receptors.

Lang M, Moradi-Chameh H, Zahid T, Gane J, Wu C, Valiante T Physiol Rep. 2014; 2(4):e00278.

PMID: 24771688 PMC: 4001873. DOI: 10.14814/phy2.278.

Baclofen prevents rapid amygdala kindling in adult rats.

Wurpel J Experientia. 1994; 50(5):475-8.

PMID: 8194584 DOI: 10.1007/BF01920750.

References

Otis T, Mody I . Differential activation of GABAA and GABAB receptors by spontaneously released transmitter. J Neurophysiol. 1992; 67(1):227-35. DOI: 10.1152/jn.1992.67.1.227. View

Karlsson G, Kolb C, Hausdorf A, Portet C, Schmutz M, Olpe H . GABAB receptors in various in vitro and in vivo models of epilepsy: a study with the GABAB receptor blocker CGP 35348. Neuroscience. 1992; 47(1):63-8. DOI: 10.1016/0306-4522(92)90120-q. View

GODDARD G, McIntyre D, Leech C . A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol. 1969; 25(3):295-330. DOI: 10.1016/0014-4886(69)90128-9. View

Dutar P, Nicoll R . A physiological role for GABAB receptors in the central nervous system. Nature. 1988; 332(6160):156-8. DOI: 10.1038/332156a0. View

Shin C, Rigsbee L, McNamara J . Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. Brain Res. 1986; 398(2):370-4. DOI: 10.1016/0006-8993(86)91498-8. View

Racine R . Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972; 32(3):281-94. DOI: 10.1016/0013-4694(72)90177-0. View

Schwark W, Haluska M . Prevention of amygdala kindling with an inhibitor of gamma-aminobutyric acid uptake. Neurosci Lett. 1986; 69(1):65-9. DOI: 10.1016/0304-3940(86)90415-5. View

Waldmeier P, Wicki P, Feldtrauer J, Baumann P . Potential involvement of a baclofen-sensitive autoreceptor in the modulation of the release of endogenous GABA from rat brain slices in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1988; 337(3):289-95. DOI: 10.1007/BF00168841. View

Scanziani M, Gahwiler B, Thompson S . Paroxysmal inhibitory potentials mediated by GABAB receptors in partially disinhibited rat hippocampal slice cultures. J Physiol. 1991; 444:375-96. PMC: 1179939. DOI: 10.1113/jphysiol.1991.sp018884. View

10.

Kalichman M, LIVINGSTON K, Burnham W . Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat. Exp Neurol. 1981; 74(3):829-36. DOI: 10.1016/0014-4886(81)90255-7. View

11.

Karlsson G, Pozza M, Olpe H . Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex. Eur J Pharmacol. 1988; 148(3):485-6. DOI: 10.1016/0014-2999(88)90136-7. View

12.

Wurpel J, Sperber E, Moshe S . Baclofen inhibits amygdala kindling in immature rats. Epilepsy Res. 1990; 5(1):1-7. DOI: 10.1016/0920-1211(90)90060-9. View

13.

Schmutz M, Klebs K, Baltzer V . Inhibition or enhancement of kindling evolution by antiepileptics. J Neural Transm. 1988; 72(3):245-57. DOI: 10.1007/BF01243423. View

14.

Olpe H, Karlsson G, Pozza M, Brugger F, Steinmann M, van Riezen H . CGP 35348: a centrally active blocker of GABAB receptors. Eur J Pharmacol. 1990; 187(1):27-38. DOI: 10.1016/0014-2999(90)90337-6. View