Mitogen-activated Protein Kinases: Versatile Transducers for Cell Signaling

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1992 Jun 1

PMID 1323888

Citations 107

Authors

S L Pelech

J S Sanghera

Affiliations

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Abstract

Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine protein kinases that are activated via phosphorylation of their own tyrosine residues. Highly conserved during eukaryotic evolution, they serve as common signaling components in distinct transduction pathways initiated by many stimuli. They have been implicated in the control of a broad spectrum of cellular events but are particularly known for their possible roles in cell cycle progression and the control of meiosis.

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