Multiple Roles of the Mitogen-activated Protein Kinase Kinase/mitogen-activated Protein Kinase Cascade in Xenopus Laevis

Overview

Journal Dev Growth Differ

Specialties Biology
Reproductive Medicine

Date 2023 Jun 7

PMID 37281037

Authors

Hidetaka Kosako

Yukiko Gotoh

Eisuke Nishida

Affiliations

Soon will be listed here.

Abstract

Mitogen-activated protein kinase (MAPK) was originally identified as a serine/threonine protein kinase that is rapidly activated in response to various growth factors and tumor promoters in mammalian cultured cells. The kinase cascade including MAPK and its direct activator, MAPK kinase (MAPKK), is now believed to transmit various extracellular signals into their intracellular targets in eukaryotic cells. It has been reported that activation of MAPKK and MAPK occurs during the meiotic maturation of oocytes in several species, including Xenopus laevis. Studies with neutralizing antibodies against MAPKK, MAPK phosphatases and constitutively active MAPKK or MAPK have revealed a crucial role of the MAPKK/MAPK cascade in a number of developmental processes in Xenopus oocytes and embryos.

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