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The Existence of Two Forms of Hypertensin

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1954 Mar 1
PMID 13130799
Citations 61
Authors
L T SKEGGS Jr
W H MARSH
J R Kahn
N P Shumway
Affiliations
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Abstract

Two types of hypertensin have been demonstrated by means of counter-current distribution. The first type is the product of the action of the enzyme, renin, upon its substrate and has been designated hypertensin I. It can be rapidly converted to a second approximately equally pressor compound, hypertensin II, apparently through the action of an enzyme in the plasma which requires halide or nitrate for activation. A highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.

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References
1.
KATZ Y, GOLDBLATT H . STUDIES ON EXPERIMENTAL HYPERTENSION : XXI. THE PURIFICATION OF RENIN. J Exp Med. 2009; 78(1):67-74. PMC: 2135367. DOI: 10.1084/jem.78.1.67. View
2.
SKEGGS Jr L, Kahn J, Shumway N . The isolation and assay of hypertensin from blood. J Exp Med. 1952; 95(3):241-6. PMC: 2212071. DOI: 10.1084/jem.95.3.241. View
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Kahn J, SKEGGS L, Shumway N . The isolation of hypertensin from the circulating blood of dogs by dialysis in an artificial kidney. Circulation. 1950; 2(3):363-8. DOI: 10.1161/01.cir.2.3.363. View
4.
SKEGGS Jr L, LEONARDS J, HEISLER C . Artificial kidney; construction and operation of an improved continuous dialyzer. Proc Soc Exp Biol Med. 1949; 72(3):539-43. DOI: 10.3181/00379727-72-17491. View
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Kahn J, SKEGGS Jr L, Shumway N, WISENBAUGH P . The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings. J Exp Med. 1952; 95(6):523-9. PMC: 2212091. DOI: 10.1084/jem.95.6.523. View