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Studies on the Pathogenesis of Fever. I. The Effect of Injection of Extracts and Suspensions of Uninfected Rabbit Tissues Upon the Body Temperature of Normal Rabbits

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1953 Nov 1
PMID 13109104
Citations 49
Authors
I L BENNETT Jr
P B Beeson
Affiliations
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Abstract

Injection of extracts or suspensions of various rabbit tissues was found to be without effect upon the body temperature of normal rabbits. Occasionally, extracts of bone marrow produced transient fever, and saline extracts of acute inflammatory lesions of the Shwartzman and Arthus types were found to produce fever when injected intravenously. Suspensions or extracts of polymorphonuclear leukocytes collected from sterile peritoneal exudates contain a heat-labile substance which produced fever whereas those of erythrocytes, macrophages, and lymphocytes failed to do so. The cell-free supernatant fluid of sterile peritoneal exudates obtained at the stage when polymorphonuclear leukocytes predominate also proved capable of producing fever.

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References
1.
Wagner R, BENNETT Jr I, LeQUIRE V . The production of fever by influenzal viruses; factors influencing the febrile response to single injections of virus. J Exp Med. 1949; 90(4):321-34. PMC: 2135916. DOI: 10.1084/jem.90.4.321. View
2.
STETSON Jr C . Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis. J Exp Med. 1951; 93(5):489-504. PMC: 2136038. DOI: 10.1084/jem.93.5.489. View
3.
MUDD S, Lucke B, McCutcheon M, Strumia M . ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : I. CORRELATION BETWEEN CHANGES IN BACTERIAL SURFACE PROPERTIES AND IN PHAGOCYTOSIS CAUSED BY SERA OF ANIMALS UNDER IMMUNIZATION. J Exp Med. 2009; 49(5):779-95. PMC: 2131589. DOI: 10.1084/jem.49.5.779. View
4.
BENNETT Jr I . A study of the relationship between the fevers caused by bacterial pyrogens and by the intravenous injection of the sterile exudates of acute inflammation. J Exp Med. 1948; 88(3):279-84. PMC: 2135827. DOI: 10.1084/jem.88.3.279. View
5.
BENNETT Jr I . A study of the relationship between the fever caused by bacterial pyrogens and the fever accompanying acute infections. J Exp Med. 1948; 88(3):267-78. PMC: 2135830. DOI: 10.1084/jem.88.3.267. View