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Induced Malignancy in Cells from Rat Myocardium Subjected to Intermittent Anaerobiosis During Long Propagation in Vitro

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1953 Apr 1
PMID 13052818
Citations 19
Authors
H GOLDBLATT
G Cameron
Affiliations
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Abstract

In two strains of fibroblasts originating from fragments of myocardium from a 5 day old rat of the Slonaker-Addis strain, a strain known to develop tumors but rarely, abnormal morphologic alterations took place which eventuated in neoplastic changes. This happened only after repeated exposure of the cultures to an atmosphere of nitrogen (anaerobiosis) and did not occur in the control cultures of fibroblasts originating from the same rat heart, and grown continuously throughout the same period (2 (1/2) years) without exposure to nitrogen.

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