Role of Hepatitis B Virus Infection in Pathogenesis of IgA Nephropathy

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2003 Sep 13

PMID 12970894

Citations 14

Authors

Nian-Song Wang

Zhao-Long Wu

Yue-E Zhang

Mu-yi Guo

Lv-Tan Liao

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the role of hepatitis B virus (HBV) in the pathogenesis of IgA nephropathy (IgAN).

Methods: HBV antigens (HBAg, or HBsAg, HBcAg, and HBeAg) in renal tissues with IgAN were detected by immunohistochemical technique. The distribution and localization of HBV DNA were observed by using in situ hybridization. Southern blot analysis was performed to reveal the state of renal HBV DNA.

Results: Among 100 patients with IgAN, HBs antigenemia was detected in 18 patients (18.00 %). HBAg in renal tissues was detected in 31 patients (31.00 %), the positive rate of HBAg, HBsAg and HBcAg was 64.52 % (20/31), 32.26 % (10/31), 32.26 % (10/31), respectively in glomeruli. HBcAg was also found in tubular epithelia and interstitia, which was 45.16 % (14/31) and 6.45 % (2/31), respectively. Five out of six cases with positive HBV DNA by in situ hybridization were proved to be HBV DNA positive by Southern blot analysis, and all were of the integrated form. Eight specimens were demonstrated to be HBV DNA positive by in situ hybridization, which was localized in the nuclei of tubular epithelial cells and glomerular mesangial cells as well as in infiltrated interstitial lymphocytes.

Conclusion: There is a relationship between HBV infection and IgAN. In addition to the humoral immune damage mediated by HBAg-HBAb immune complex, the cellular mechanism mediated by HBV originating from renal cells in situ may be also involved in the pathogenesis of IgAN.

Citing Articles

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Rapidly Progressive Glomerulonephritis Associated With IgA Nephropathy and C3 Deposits in a Patient With Chronic Hepatitis B.

Wiese J, Derian N, Turki M, Joshi T, Alsanani A, Satoskar A Cureus. 2024; 16(10):e70619.

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Hepatitis B Virus Status and Clinical Outcomes in IgA Nephropathy.

Gao M, Xu L, Li Y, Wang X, Chen P, Shi S Kidney Int Rep. 2024; 9(4):1057-1066.

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Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections.

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Clinicopathological features, risk factors, and outcomes of immunoglobulin A nephropathy associated with hepatitis B virus infection.

Wang K, Yu Z, Huang Y, Yang K, He T, Xiao T J Nephrol. 2021; 34(6):1887-1896.

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References

Knieser M, Jenis E, Lowenthal D, Bancroft W, Burns W, SHALHOUB R . Pathogenesis of renal disease associated with viral hepatitis. Arch Pathol. 1974; 97(4):193-200. View

Combes B, Shorey J, Barrera A, Stastny P, Eigenbrodt E, HULL A . Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane. Lancet. 1971; 2(7718):234-7. DOI: 10.1016/s0140-6736(71)92572-4. View

Ito H, Hattori S, Matusda I, Amamiya S, HAJIKANO H, Yoshizawa H . Hepatitis B e antigen-mediated membranous glomerulonephritis. Correlation of ultrastructural changes with HBeAg in the serum and glomeruli. Lab Invest. 1981; 44(3):214-20. View

Lin C . Treatment of hepatitis B virus-associated membranous nephropathy with recombinant alpha-interferon. Kidney Int. 1995; 47(1):225-30. DOI: 10.1038/ki.1995.27. View

Zhang Y, Guo M, Ying Y . [Further study on the immunopathology of hepatitis B virus associated glomerulonephritis]. Zhonghua Nei Ke Za Zhi. 1990; 29(9):526-9, 574. View

Thyagarajan S, Thirunalasundari T, Subramanian S, Panchanadam M, Nammalwar B, Prabha V . Serum and tissue positivity for hepatitis B virus markers in histopathologically proven glomerulonephropathies. J Med Microbiol. 1989; 29(4):243-9. DOI: 10.1099/00222615-29-4-243. View

Nolasco F, Cameron J, Hartley B, Coelho A, HILDRETH G, Reuben R . Intraglomerular T cells and monocytes in nephritis: study with monoclonal antibodies. Kidney Int. 1987; 31(5):1160-6. DOI: 10.1038/ki.1987.123. View

Lin C . Hepatitis B virus deoxyribonucleic acid in kidney cells probably leading to viral pathogenesis among hepatitis B virus associated membranous nephropathy patients. Nephron. 1993; 63(1):58-64. DOI: 10.1159/000187144. View

Li L, Li L, Chen H, Zhou H, Ji D, Tang Z . Primary glomerulonephritis in China. Analysis of 1001 cases. Chin Med J (Engl). 1989; 102(3):159-64. View

10.

Dejean A, Lugassy C, Zafrani S, Tiollais P, Brechot C . Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus. J Gen Virol. 1984; 65 ( Pt 3):651-5. DOI: 10.1099/0022-1317-65-3-651. View

11.

BRZOSKO W, Krawczynski K, NAZAREWICZ T, MORZYCKA M, NOWOSLAWSKI A . Glomerulonephritis associated with hepatitis-B surface antigen immune complexes in children. Lancet. 1974; 2(7879):477-82. DOI: 10.1016/s0140-6736(74)92012-1. View

12.

Hirose H, Udo K, Kojima M, Takahashi Y, Miyakawa Y, Miyamoto K . Deposition of hepatitis B e antigen in membranous glomerulonephritis: identification by F(ab')2 fragments of monoclonal antibody. Kidney Int. 1984; 26(3):338-41. DOI: 10.1038/ki.1984.178. View

13.

Lai K, Tam J, Lin H, Lai F . The therapeutic dilemma of the usage of corticosteroid in patients with membranous nephropathy and persistent hepatitis B virus surface antigenaemia. Nephron. 1990; 54(1):12-7. DOI: 10.1159/000185802. View

14.

Nagy J, BAJTAI G, Brasch H, Sule T, Ambrus M, Deak G . The role of hepatitis B surface antigen in the pathogenesis of glomerulopathies. Clin Nephrol. 1979; 12(3):109-16. View

15.

Araki K, Miyazaki J, Hino O, Tomita N, Chisaka O, Matsubara K . Expression and replication of hepatitis B virus genome in transgenic mice. Proc Natl Acad Sci U S A. 1989; 86(1):207-11. PMC: 286433. DOI: 10.1073/pnas.86.1.207. View

16.

Magil A . IgA nephropathy and membranous nephropathy associated with hepatitis B surface antigenemia. Hum Pathol. 1988; 19(5):615. DOI: 10.1016/s0046-8177(88)80218-1. View

17.

Gauthier V, Striker G, Mannik M . Glomerular localization of preformed immune complexes prepared with anionic antibodies or with cationic antigens. Lab Invest. 1984; 50(6):636-44. View

18.

Zhou W, Zhang W, Geng L . [Glomerulonephropathy associated with hepatitis B virus (HBV) infection]. Zhonghua Nei Ke Za Zhi. 1990; 29(9):530-3, 574. View

19.

Takeda S, Kida H, Katagiri M, Yokoyama H, Abe T, Hattori N . Characteristics of glomerular lesions in hepatitis B virus infection. Am J Kidney Dis. 1988; 11(1):57-62. DOI: 10.1016/s0272-6386(88)80176-8. View

20.

Farza H, Hadchouel M, Scotto J, Tiollais P, Babinet C, Pourcel C . Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J Virol. 1988; 62(11):4144-52. PMC: 253846. DOI: 10.1128/JVI.62.11.4144-4152.1988. View