Increased Expression of Seprase, a Membrane-type Serine Protease, is Associated with Lymph Node Metastasis in Human Colorectal Cancer

Overview

Journal Cancer Lett

Specialty Oncology

Date 2003 Sep 10

PMID 12963128

Citations 27

Authors

Satoshi Iwasa

Xin Jin

Kyoko Okada

Masako Mitsumata

Akishi Ooi

Affiliations

Soon will be listed here.

Abstract

Seprase is a membrane-bound serine proteinase with gelatinase activity, which may be involved in cancer invasion and metastasis. We examined seprase expression in colorectal cancer specimens obtained from 109 patients. Seprase immunoreactivity was found in cancer cells and adjacent stromal cells. Immunoblotting showed higher levels of seprase protein in colorectal cancer tissue than in normal colorectal tissue. A semiquantitative assessment of the immunohistochemistry results revealed a significant correlation between seprase expression and lymph node metastasis. These results suggested that an abundant expression of seprase in colorectal cancer tissue is associated with lymph node metastasis.

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