Cyclin-dependent Kinase 4 Inhibitors As a Treatment for Cancer. Part 2: Identification and Optimisation of Substituted 2,4-bis Anilino Pyrimidines

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2003 Aug 28

PMID 12941312

Citations 10

Authors

Gloria A Breault

Rebecca P A Ellston

Stephen Green

S Russell James

Philip J Jewsbury

Catherine J Midgley

Richard A Pauptit

Claire A Minshull

Julie A Tucker

J Elizabeth Pease

Affiliations

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Abstract

Through chemical modification and X-ray crystallography we identified the 2,4-bis anilino pyrimidines as potent inhibitors of CDK4. Herein, we describe the optimisation of this series.

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