Efficacy of Linezolid Alone or in Combination with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-resistant Staphylococcus Aureus

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2003 Aug 26

PMID 12937013

Citations 23

Authors

Fu-Yu Chiang

Michael Climo

Affiliations

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Abstract

The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.

Citing Articles

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Antagonistic Effect of Colistin on Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus in and Studies.

Choi S, Moon S, Park S, Lee S, Jung K, Sung H Antimicrob Agents Chemother. 2020; 64(4).

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Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness.

Randolph A, Xu R, Novak T, Newhams M, Bubeck Wardenburg J, Weiss S Clin Infect Dis. 2018; 68(3):365-372.

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Combination of Tedizolid and Daptomycin against Methicillin-Resistant Staphylococcus aureus in an Model of Simulated Endocardial Vegetations.

Smith J, Yim J, Rice S, Stamper K, Kebriaei R, Rybak M Antimicrob Agents Chemother. 2018; 62(5).

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A complicated prosthetic valve endocarditis due to methicillin resistant Staphylococci treated with linezolid and ciprofloxacin: a case report.

Amiyangoda C, Wimalaratna H, Bowatte S BMC Res Notes. 2017; 10(1):580.

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