Accumulation of Clostridium Perfringens Epsilon-toxin in the Mouse Kidney and Its Possible Biological Significance

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2003 Aug 23

PMID 12933886

Citations 29

Authors

Eiji Tamai

Tetsuya Ishida

Shigeru Miyata

Osamu Matsushita

Hirofumi Suda

Shoji Kobayashi

Hiroshi Sonobe

Akinobu Okabe

Affiliations

Soon will be listed here.

Abstract

In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.

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