Virus-receptor Interactions of Coxsackie B Viruses and Their Putative Influence on Cardiotropism

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 2003 Aug 16

PMID 12920584

Citations 21

Authors

Hans-Christoph Selinka

Antje Wolde

Martina Sauter

Reinhard Kandolf

Karin Klingel

Affiliations

Soon will be listed here.

Abstract

Specific virus-receptor interactions are important determinants in the pathogenesis of viral infections, influencing the location and initiation of primary infection as well as the viral spread to other target organs in the postviremic phase. Coxsackieviruses of group B (CVB) specifically interact with at least two receptor proteins, the coxsackievirus-adenovirus receptor (CAR) and the decay-accelerating factor (DAF), and cause a broad spectrum of diseases, including acute and chronic myocarditis. In the human heart, CAR is predominantly expressed in intercalated discs, regions of utmost importance for the functional integrity of the heart. Since DAF is abundantly expressed in epithelial and endothelial cells, interaction of cardiotropic CVB with the DAF coreceptor protein, in addition to CAR, could therefore be advantageous to the virus by enhancing viral entry into the heart.

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References

Cohen C, Shieh J, Pickles R, Okegawa T, Hsieh J, Bergelson J . The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci U S A. 2001; 98(26):15191-6. PMC: 65005. DOI: 10.1073/pnas.261452898. View

Barton E, Forrest J, Connolly J, Chappell J, Liu Y, Schnell F . Junction adhesion molecule is a receptor for reovirus. Cell. 2001; 104(3):441-51. DOI: 10.1016/s0092-8674(01)00231-8. View

de Verdugo U, Selinka H, Huber M, Kramer B, KELLERMANN J, Hofschneider P . Characterization of a 100-kilodalton binding protein for the six serotypes of coxsackie B viruses. J Virol. 1995; 69(11):6751-7. PMC: 189586. DOI: 10.1128/JVI.69.11.6751-6757.1995. View

Carson S, Chapman N, Tracy S . Purification of the putative coxsackievirus B receptor from HeLa cells. Biochem Biophys Res Commun. 1997; 233(2):325-8. DOI: 10.1006/bbrc.1997.6449. View

Nisole S, Krust B, Hovanessian A . Anchorage of HIV on permissive cells leads to coaggregation of viral particles with surface nucleolin at membrane raft microdomains. Exp Cell Res. 2002; 276(2):155-73. DOI: 10.1006/excr.2002.5522. View

Opavsky M, Martino T, Rabinovitch M, Penninger J, Richardson C, Petric M . Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. J Clin Invest. 2002; 109(12):1561-9. PMC: 151008. DOI: 10.1172/JCI13971. View

Martino T, Petric M, Brown M, Aitken K, Gauntt C, Richardson C . Cardiovirulent coxsackieviruses and the decay-accelerating factor (CD55) receptor. Virology. 1998; 244(2):302-14. DOI: 10.1006/viro.1998.9122. View

Bergelson J, Modlin J, Cunningham J, CROWELL R, Finberg R . Clinical coxsackievirus B isolates differ from laboratory strains in their interaction with two cell surface receptors. J Infect Dis. 1997; 175(3):697-700. DOI: 10.1093/infdis/175.3.697. View

Huber M, Selinka H, Kandolf R . Tyrosine phosphorylation events during coxsackievirus B3 replication. J Virol. 1997; 71(1):595-600. PMC: 191089. DOI: 10.1128/JVI.71.1.595-600.1997. View

10.

Martino T, Liu P, Sole M . Viral infection and the pathogenesis of dilated cardiomyopathy. Circ Res. 1994; 74(2):182-8. DOI: 10.1161/01.res.74.2.182. View

11.

Noutsias M, Fechner H, de Jonge H, Wang X, Dekkers D, Houtsmuller A . Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation. 2001; 104(3):275-80. DOI: 10.1161/01.cir.104.3.275. View

12.

Hovanessian A, Nisole S, Svab J, Perret E, Deng J, Krust B . The cell-surface-expressed nucleolin is associated with the actin cytoskeleton. Exp Cell Res. 2000; 261(2):312-28. DOI: 10.1006/excr.2000.5071. View

13.

Shafren D, Bates R, Agrez M, Herd R, Burns G, BARRY R . Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment. J Virol. 1995; 69(6):3873-7. PMC: 189108. DOI: 10.1128/JVI.69.6.3873-3877.1995. View

14.

Tomko R, Xu R, Philipson L . HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997; 94(7):3352-6. PMC: 20373. DOI: 10.1073/pnas.94.7.3352. View

15.

Klingel K, Rieger P, Mall G, Selinka H, Huber M, Kandolf R . Visualization of enteroviral replication in myocardial tissue by ultrastructural in situ hybridization: identification of target cells and cytopathic effects. Lab Invest. 1998; 78(10):1227-37. View

16.

Kandolf R, Klingel K, Zell R, Selinka H, Raab U, Schneider-Brachert W . Molecular pathogenesis of enterovirus-induced myocarditis: virus persistence and chronic inflammation. Intervirology. 1993; 35(1-4):140-51. DOI: 10.1159/000150305. View

17.

Bergelson J, Cunningham J, Droguett G, Krithivas A, Hong J, Horwitz M . Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 1997; 275(5304):1320-3. DOI: 10.1126/science.275.5304.1320. View

18.

Luo H, Yanagawa B, Zhang J, Luo Z, Zhang M, Esfandiarei M . Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. J Virol. 2002; 76(7):3365-73. PMC: 136021. DOI: 10.1128/jvi.76.7.3365-3373.2002. View

19.

Selinka H, Wolde A, Pasch A, Klingel K, Kupper J, Lindberg A . Comparative analysis of two coxsackievirus B3 strains: putative influence of virus-receptor interactions on pathogenesis. J Med Virol. 2002; 67(2):224-33. DOI: 10.1002/jmv.2211. View

20.

Huber M, Watson K, Selinka H, Carthy C, Klingel K, McManus B . Cleavage of RasGAP and phosphorylation of mitogen-activated protein kinase in the course of coxsackievirus B3 replication. J Virol. 1999; 73(5):3587-94. PMC: 104132. DOI: 10.1128/JVI.73.5.3587-3594.1999. View