Seroprevalence of Helicobacter Pylori in School-aged Chinese in Taipei City and Relationship Between ABO Blood Groups

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2003 Aug 15

PMID 12918114

Citations 9

Authors

Tzee-Chung Wu

Liang-Kung Chen

Shinn-Jang Hwang

Affiliations

Soon will be listed here.

Abstract

Aim: To explore the seropositive rate of antibodies against H. pylori (anti-HP) in Taipei City and to compare the relationship of ABO blood groups and H. pylori infection.

Methods: In 1993, high school students in Shih-Lin District were randomly selected for blood samplings by their registration number at school. In addition, similar procedures were performed on the well-children clinics of Taipei Veterans General Hospital. Besides, randomly selected sera from the adults who took the physical examination were recruited for evaluation. Informed consents were obtained from all the subjects before blood samplings and parents were simultaneously informed for those who were younger than 18-year-old. Blood tests for anti-HP and ABO blood groupings were performed by enzyme-linked immunosorbent assay. Chi square tests were used for the comparisons between seroprevalence of H. pylori and ABO blood groups.

Results: Totally, 685 subjects were recruited (260 children aged 1-14 years, 425 high school students aged 15-18 years) were evaluated, and another 88 adult healthy volunteers were studied as well for comparison. The age-specific seropositive rate of anti-HP was 1.3 % at age 1-5 years, 7.7 % at age 6-10 years, and 11.5 % at age 11-14 years. The seroprevalence of H. pylori infection was abruptly increased in young adolescence: 18.6 % at age 15 years, 28.1 % at age 16 years, 32.4 % at age 17 years and 41.0 % at age 18 years, respectively. In the 425 high school students, ABO blood groupings were performed, which disclosed 48.5 % (206/425) of blood group O, 24 % (102/425) of blood group A, 21.8 % (93/425) of blood group B and 5.6 % (24/425) of blood group AB. In comparison of the subjects with blood group O and the other blood groups, no statistical significance could be identified in the seroprevalence of H. pylori (P=0.99).

Conclusion: The seroprevalence of H. pylori infection in Taipei City in adults is similar to the developed countries, and the abrupt increase of H. pylori during high school may be resulted from marked increase of interpersonal social activities. Although blood group O was reported to be related to H. pylori infection in previous literature, we found no association between H. pylori infection and ABO blood groups.

Citing Articles

Association Between Helicobacter pylori Infection and Serum Iron Profile.

Kishore G, Ejaz M, Kumar J, Lal A, Tahir H, Anjum Z Cureus. 2021; 13(9):e17925.

PMID: 34660117 PMC: 8513126. DOI: 10.7759/cureus.17925.

Blood Groups in Infection and Host Susceptibility.

Cooling L Clin Microbiol Rev. 2015; 28(3):801-70.

PMID: 26085552 PMC: 4475644. DOI: 10.1128/CMR.00109-14.

Risk of advanced gastric precancerous lesions in Helicobacter pylori infected subjects is influenced by ABO blood group and cagA status.

Rizzato C, Kato I, Plummer M, Munoz N, Stein A, van Doorn L Int J Cancer. 2013; 133(2):315-22.

PMID: 23319424 PMC: 3656130. DOI: 10.1002/ijc.28019.

Sex-specific differences in the association between ABO genotype and gastric cancer risk in a Korean population.

Song H, Shin M, Kim H, Piao J, Choi J, Hwang J Gastric Cancer. 2012; 16(2):254-60.

PMID: 22865192 DOI: 10.1007/s10120-012-0176-z.

Agreement rate of rapid urease test, conventional PCR, and scorpion real-time PCR in detecting helicobacter pylori from tonsillar samples of patients with chronic tonsillitis.

Najafipour R, Naserpour Farivar T, Pahlevan A, Johari P, Safdarian F, Asefzadeh M J Glob Infect Dis. 2012; 4(2):106-9.

PMID: 22754245 PMC: 3385199. DOI: 10.4103/0974-777X.96773.

References

Oderda G, Vaira D, Holton J . Age-related increase of Helicobacter pylori frequency in symptom-free and in dyspeptic children. Lancet. 1992; 340(8820):671-2. DOI: 10.1016/0140-6736(92)92204-s. View

Lin D, Tsai T, Yang C, Wang H, Nieh W, Ling U . Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori. Am J Trop Med Hyg. 2001; 63(3-4):189-91. DOI: 10.4269/ajtmh.2000.63.189. View

Niv Y, Fraser G, Delpre G, Neeman A, Leiser A, Samra Z . Helicobacter pylori infection and blood groups. Am J Gastroenterol. 1996; 91(1):101-4. View

Brenner H, Rothenbacher D, Bode G, Adler G . Relation of smoking and alcohol and coffee consumption to active Helicobacter pylori infection: cross sectional study. BMJ. 1998; 315(7121):1489-92. PMC: 2127930. DOI: 10.1136/bmj.315.7121.1489. View

Wizla-Derambure N, Michaud L, Ategbo S, Vincent P, Ganga-Zandzou S, Turck D . Familial and community environmental risk factors for Helicobacter pylori infection in children and adolescents. J Pediatr Gastroenterol Nutr. 2001; 33(1):58-63. DOI: 10.1097/00005176-200107000-00010. View

Lin J, Wang J, Wang T, Wu M, Lee T, Chen C . Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. A seroprevalence study in Taiwan. Scand J Gastroenterol. 1993; 28(12):1067-72. DOI: 10.3109/00365529309098311. View

Wang L, Lin J, Cheng Y, Chou S, Chen C . Seroepidemiology of Helicobacter pylori among adolescents in Taiwan. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1996; 29(1):10-7. View

De Giacomo C, Lisato L, Negrini R, Licardi G, Maggiore G . Serum immune response to Helicobacter pylori in children: epidemiologic and clinical applications. J Pediatr. 1991; 119(2):205-10. DOI: 10.1016/s0022-3476(05)80728-0. View

Megraud F . Epidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am. 1993; 22(1):73-88. View

10.

Rauws E, Tytgat G . Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet. 1990; 335(8700):1233-5. DOI: 10.1016/0140-6736(90)91301-p. View

11.

Stone M, Taub N, Barnett D, Mayberry J . Increased risk of infection with Helicobacter pylori in spouses of infected subjects: observations in a general population sample from the UK. Hepatogastroenterology. 2000; 47(32):433-6. View

12.

Atherton J, Tham K, Peek Jr R, Cover T, Blaser M . Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis. 1996; 174(3):552-6. DOI: 10.1093/infdis/174.3.552. View

13.

Sullivan P, Thomas J, Wight D, Neale G, Eastham E, Corrah T . Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition. Arch Dis Child. 1990; 65(2):189-91. PMC: 1792228. DOI: 10.1136/adc.65.2.189. View

14.

Fiedorek S, Malaty H, Evans D, Pumphrey C, Casteel H, Evans Jr D . Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics. 1991; 88(3):578-82. View

15.

Lin D, Nieh W, Wang H, Hsiao M, Ling U, Changlai S . Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan. Am J Trop Med Hyg. 1999; 61(4):554-8. DOI: 10.4269/ajtmh.1999.61.554. View

16.

Nomura A, STEMMERMANN G . Helicobacter pylori and gastric cancer. J Gastroenterol Hepatol. 1993; 8(3):294-303. DOI: 10.1111/j.1440-1746.1993.tb01202.x. View

17.

Lin C, Chang Y, Wu S, Cheng K . Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases. Jpn J Med Sci Biol. 1999; 51(1):13-23. DOI: 10.7883/yoken1952.51.13. View

18.

Tindberg Y, Bengtsson C, Granath F, Blennow M, Nyren O, Granstrom M . Helicobacter pylori infection in Swedish school children: lack of evidence of child-to-child transmission outside the family. Gastroenterology. 2001; 121(2):310-6. DOI: 10.1053/gast.2001.26282. View

19.

Boren T, Falk P, Roth K, Larson G, Normark S . Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science. 1993; 262(5141):1892-5. DOI: 10.1126/science.8018146. View

20.

Ashorn M . What are the specific features of Helicobacter pylori gastritis in children?. Ann Med. 1995; 27(5):617-20. DOI: 10.3109/07853899509002480. View