Helicobacter Pylori in Gambian Children with Chronic Diarrhoea and Malnutrition

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1990 Feb 1

PMID 2317065

Citations 39

Authors

P B Sullivan

J E Thomas

D G Wight

G Neale

E J Eastham

T Corrah

B M Greenwood

Affiliations

Soon will be listed here.

Abstract

Infection with Helicobacter pylori (formerly Campylobacter pylori) was studied by measuring antibody titres to H pylori in Gambian children. Serological evidence of infection was found in 12 of 82 (15%) infants aged less than 20 months; this increased to 62 of 135 (46%) in those aged 40-60 months. Positive serology was found in 41 of 77 (53%) infants with chronic diarrhoea and malnutrition (mean age 19 months, range 5-36) compared with 18 of 70 (26%) of age matched healthy controls and nearly a quarter (12/49, 24%) of age matched undernourished (marasmic) subjects. These data show that infection with H pylori is common in the Gambia and that in infancy this infection is associated with chronic diarrhoea and malnutrition.

Citing Articles

Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016.

Mehata S, Parajuli K, Pant N, Rayamajhee B, Yadav U, Mehta R PLoS Negl Trop Dis. 2021; 15(6):e0009510.

PMID: 34153049 PMC: 8263064. DOI: 10.1371/journal.pntd.0009510.

Infection, Virulence Genes' Distribution and Accompanying Clinical Outcomes: The West Africa Situation.

Ofori E, Adinortey C, Bockarie A, Kyei F, Tagoe E, Adinortey M Biomed Res Int. 2019; 2019:7312908.

PMID: 31886245 PMC: 6925786. DOI: 10.1155/2019/7312908.

Atrophic gastritis and chronic diarrhea due to Helicobacter pylori infection in early infancy: A case report.

Kakiuchi T, Nakayama A, Shimoda R, Matsuo M Medicine (Baltimore). 2019; 98(47):e17986.

PMID: 31764809 PMC: 6882621. DOI: 10.1097/MD.0000000000017986.

Association between infection with and platelet indices among school-aged children in central Ethiopia: a cross-sectional study.

Baxendell K, Walelign S, Tesfaye M, Wordofa M, Abera D, Mesfin A BMJ Open. 2019; 9(4):e027748.

PMID: 30962240 PMC: 6500313. DOI: 10.1136/bmjopen-2018-027748.

Helicobacter pylori infection and risk of salmonella infection.

Salama R, Emara M, Mostafa H, Abd-Elsalam S, Alnabawy S, Elshweikh S Medicine (Baltimore). 2019; 98(6):e14335.

PMID: 30732157 PMC: 6380853. DOI: 10.1097/MD.0000000000014335.

References

Giannella R, Broitman S, ZAMCHECK N . Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972; 13(4):251-6. PMC: 1412163. DOI: 10.1136/gut.13.4.251. View

Cave D, Vargas M . Effect of a Campylobacter pylori protein on acid secretion by parietal cells. Lancet. 1989; 2(8656):187-9. DOI: 10.1016/s0140-6736(89)90372-3. View

Gracey M, Cullity G, Suharjono , Sunoto . The stomach in malnutrition. Arch Dis Child. 1977; 52(4):325-7. PMC: 1544650. DOI: 10.1136/adc.52.4.325. View

Ulshen M, Rollo J . Pathogenesis of escherichia coli gastroenteritis in man--another mechanism. N Engl J Med. 1980; 302(2):99-101. DOI: 10.1056/NEJM198001103020207. View

Warren J, Marshall B . Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983; 1(8336):1273-5. View

Gledhill T, Leicester R, Addis B, Lightfoot N, Barnard J, Viney N . Epidemic hypochlorhydria. Br Med J (Clin Res Ed). 1985; 290(6479):1383-6. PMC: 1415635. DOI: 10.1136/bmj.290.6479.1383. View

Jones D, Eldridge J, Fox A, Sethi P, Whorwell P . Antibody to the gastric campylobacter-like organism ("Campylobacter pyloridis")--clinical correlations and distribution in the normal population. J Med Microbiol. 1986; 22(1):57-62. DOI: 10.1099/00222615-22-1-57. View

Morris A, Nicholson G . Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol. 1987; 82(3):192-9. View

Jones D, Eldridge J, Whorwell P . Antibodies to Campylobacter pyloridis in household contacts of infected patients. Br Med J (Clin Res Ed). 1987; 294(6572):615. PMC: 1245657. DOI: 10.1136/bmj.294.6572.615-a. View

10.

Kern S, Keren D, Pierson C . Bacterial overgrowth and mucosal changes in isolated (Thirty-Vella) ileal loops in rabbits. Effects of intraluminal antibiotics. Lab Invest. 1987; 57(3):336-41. View

11.

Berkowicz J, Lee A . Person-to-person transmission of Campylobacter pylori. Lancet. 1987; 2(8560):680-1. DOI: 10.1016/s0140-6736(87)92458-5. View

12.

Mitchell H, Bohane T, Berkowicz J, Hazell S, Lee A . Antibody to Campylobacter pylori in families of index children with gastrointestinal illness due to C pylori. Lancet. 1987; 2(8560):681-2. DOI: 10.1016/s0140-6736(87)92459-7. View

13.

Gilman R, Partanen R, Brown K, Spira W, Khanam S, Greenberg B . Decreased gastric acid secretion and bacterial colonization of the stomach in severely malnourished Bangladeshi children. Gastroenterology. 1988; 94(6):1308-14. DOI: 10.1016/0016-5085(88)90668-3. View

14.

Sullivan P, Phillips M, Neale G . Endoscopic capsule biopsy of the small intestine. J Pediatr Gastroenterol Nutr. 1988; 7(4):544-7. DOI: 10.1097/00005176-198807000-00011. View

15.

Wagner S, Freise J, Beholz S, Schmidt F . Campylobacter pylori and gastric acidity. Am J Gastroenterol. 1989; 84(2):201-2. View

16.

Gracey M, Stone D . Small-intestinal microflora in Autralian Aboriginal children with chronic diarrhoea. Aust N Z J Med. 1972; 2(3):215-9. DOI: 10.1111/j.1445-5994.1972.tb03065.x. View