Chemoprevention of Colon Cancer by Calcium, Vitamin D and Folate: Molecular Mechanisms

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2003 Aug 2

PMID 12894248

Citations 182

Authors

Sergio A Lamprecht

Martin Lipkin

Affiliations

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Abstract

Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.

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