The Effect of Vitamin D on the Occurrence and Development of Colorectal Cancer: a Systematic Review and Meta-analysis

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2021 Feb 18

PMID 33598751

Citations 7

Authors

Yunbao Xu

Mingxia Qian

Jiaze Hong

Derry Minyao Ng

Tong Yang

Liuhong Xu

Xia Ye

Affiliations

Soon will be listed here.

Abstract

Purpose: There has been a lot of controversies about the correlation between vitamin D and colorectal cancer (CRC). In this meta-analysis, we purposed to explore the relationship between vitamin D and the incidence of CRC/the prognosis of CRC.

Methods: A systematic search for articles in databases (Pubmed, Web of Science, EBSCO and Cochrane Library) was terminated in April 2020. The primary outcomes were the incidence rate of CRC and the long-term survival of patients with CRC.

Results: According to the estimated pooled OR from 21 eligible studies, covering 904,152 people, the use of vitamin D was inversely associated with the incidence of CRC [OR = 0.87, (0.82-0.92)]. Among the four studies included in this meta-analysis, covering 7486 patients, compared the overall survival (OS) of CRC between the vitamin D users and the non-users. Based on the estimated pooled HR, vitamin D potentially improved the long-term survival of CRC patients [HR = 0.91, (0.83-0.98)].

Conclusion: This meta-analysis demonstrates that vitamin D not only has a positive impact on the incidence of CRC from either the dietary or supplemental sources but also benefits clinical outcomes and improves the long-term survival of CRC patients. However, further studies are recommended to clarify the above phenomena.

Citing Articles

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