A Neurodevelopmental Model for Anorexia Nervosa

Overview

Journal Physiol Behav

Specialties Physiology
Psychiatry
Psychology
Social Sciences

Date 2003 Jun 24

PMID 12818706

Citations 46

Authors

Frances Connan

Iain C Campbell

Melanie Katzman

Stafford L Lightman

Janet Treasure

Affiliations

Soon will be listed here.

Abstract

This paper integrates genetic and biological data on aetiological risk for anorexia nervosa (AN) with cognitive and psychosocial explanatory models. We have reviewed clinical and basic science data from each of these domains and then used a developmental perspective to formulate a multifactorial threshold model. By positioning interpersonal stress as a central component of this model, psychological, social and biological conceptualisations of AN can be used to generate a data driven, neurodevelopmental hypothesis for the aetiology of this complex disorder.

Citing Articles

Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders.

Ismaylova E, Nemoda Z, Booij L J Psychopharmacol. 2025; 39(3):187-200.

PMID: 39745000 PMC: 11843796. DOI: 10.1177/02698811241309617.

Machine learning models for diagnosis and risk prediction in eating disorders, depression, and alcohol use disorder.

Zhang Z, Robinson L, Whelan R, Jollans L, Wang Z, Nees F J Affect Disord. 2024; .

PMID: 39701465 PMC: 7617286. DOI: 10.1016/j.jad.2024.12.053.

Common genetic variants contribute more to rare diseases than previously thought.

Breen G Nature. 2024; 636(8042):304-305.

PMID: 39567806 DOI: 10.1038/d41586-024-03554-4.

Social safeness and eating disorder symptoms: a correlational study exploring associations of social safeness, eating disorder symptoms, social support and shame in a non-clinical young adult sample.

Langdon-Daly J, Chuang H, Handke A J Eat Disord. 2024; 12(1):102.

PMID: 39039534 PMC: 11265091. DOI: 10.1186/s40337-024-01057-1.

Using Electroencephalogram-Extracted Nonlinear Complexity and Wavelet-Extracted Power Rhythm Features during the Performance of Demanding Cognitive Tasks (Aristotle's Syllogisms) in Optimally Classifying Patients with Anorexia Nervosa.

Karavia A, Papaioannou A, Michopoulos I, Papageorgiou P, Papaioannou G, Gonidakis F Brain Sci. 2024; 14(3).

PMID: 38539639 PMC: 10969099. DOI: 10.3390/brainsci14030251.