A CD40 Bridge Between Innate and Adaptive Immunity

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2003 Jun 24

PMID 12818154

Citations 2

Authors

Edward A Clark

Andrew Craxton

Affiliations

Soon will be listed here.

Abstract

In this issue of Immunity, Brodeur et al. show that C4b binding protein (C4BP), a regulator component of the classical complement (C) pathway, can bind to CD40 receptors on B cells and activate them. This suggests a novel way by which CD40 may function to bridge innate and adaptive immune responses.

Citing Articles

The role of CD40 and CD154/CD40L in dendritic cells.

Ma D, Clark E Semin Immunol. 2009; 21(5):265-72.

PMID: 19524453 PMC: 2749083. DOI: 10.1016/j.smim.2009.05.010.

Macrophages pulsed with Streptococcus pneumoniae elicit a T cell-dependent antibody response upon transfer into naive mice.

Vasilevsky S, Colino J, Puliaev R, Canaday D, Snapper C J Immunol. 2008; 181(3):1787-97.

PMID: 18641316 PMC: 2561269. DOI: 10.4049/jimmunol.181.3.1787.