Human Rotavirus Strain with Unique VP4 Neutralization Epitopes As a Result of Natural Reassortment Between Members of the AU-1 and Wa Genogroups

Overview

Journal Arch Virol

Specialty Microbiology

Date 1992 Jan 1

PMID 1280946

Citations 7

Authors

O Nakagomi

E Kaga

T Nakagomi

Affiliations

Soon will be listed here.

Abstract

Human rotavirus strain K8, which possesses unique VP4 neutralization epitopes, was examined by RNA-RNA hybridization to determine its genogroup. While it possessed four gene segments that formed hybrids with strain Wa (a prototype of the Wa genogroup), strain K8 possessed seven gene segments, including gene segment 4, that formed hybrids with strain AU-1 (a prototype of the AU-1 genogroup) which has been shown to share a unique gene 4 allele with feline rotaviruses. These results suggest that strain K8 is an intergenogroup reassortant formed in nature between a member of the Wa genogroup and a member of the AU-1 genogroup.

Citing Articles

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Detection of a human rotavirus with G12 and P[9] specificity in Thailand.

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Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains.

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Recurrent circulation of single nonstructural gene substitution reassortants among human rotaviruses with a short RNA pattern.

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Rotaviruses belonging to the AU-1 genogroup recovered from Israeli infants with diarrhea.

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