Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2003 Jun 11

PMID 12796471

Citations 39

Authors

Elmar Jaeckel

Ludger Klein

Natalia Martin-Orozco

Harald von Boehmer

Affiliations

Soon will be listed here.

Abstract

Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid decarboxylase (GAD) in beta cells have suggested that GAD represents an autoantigen essential for initiating and maintaining the diabetogenic immune response. Several attempts of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we report on successful tolerance induction by expressing a modified form of GAD under control of the invariant chain promoter resulting in efficient epitope display. In spite of specific tolerance insulitis and diabetes occurred with normal kinetics indicating that GAD is not an essential autoantigen in the pathogenesis of diabetes.

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