Human Metapneumovirus Infections in Hospitalized Children

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2003 Jun 5

PMID 12781001

Citations 190

Authors

Guy Boivin

Gaston De Serres

Stephanie Cote

Rodica Gilca

Yacine Abed

Louis Rochette

Michel G Bergeron

Pierre Dery

Affiliations

Soon will be listed here.

Abstract

We evaluated the percentage of hospitalizations for acute respiratory tract infections in children < or =3 years of age attributable to human metapneumovirus (HMPV) and other respiratory viruses in a prospective study during winter and spring 2002. We used real-time polymerase chain assays and other conventional diagnostic methods to detect HMPV, human respiratory syncytial virus (HRSV), and influenza viruses in nasopharyngeal aspirates of children. HMPV was detected in 12 (6%) of the 208 children hospitalized for acute respiratory tract infections, HRSV in 118 (57%), and influenza A in 49 (24%). Bronchiolitis was diagnosed in 8 (68%) and pneumonitis in 2 (17%) of HMPV-infected children; of those with HRSV infection, bronchiolitiss was diagnosed in 99 (84%) and pneumonitis in 30 (25%). None of the HMPV-infected children was admitted to an intensive-care unit, whereas 15% of those with HRSV or influenza A infections were admitted. HMPV is an important cause of illness in young children with a similar, although less severe, clinical presentation to that of HRSV.

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