Characterization of Mammalian Selenoproteomes

Overview

Journal Science

Specialty Science

Date 2003 May 31

PMID 12775843

Citations 761

Authors

Gregory V Kryukov

Sergi Castellano

Sergey V Novoselov

Alexey V Lobanov

Omid Zehtab

Roderic Guigo

Vadim N Gladyshev

Affiliations

Soon will be listed here.

Abstract

In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.

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