Alpha Interferon Augments Cidofovir's Antiviral and Antiproliferative Activities

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2003 May 23

PMID 12760891

Authors

Jeffrey A Johnson

J David Gangemi

Affiliations

Soon will be listed here.

Abstract

The antiviral and antiproliferative activities of alpha 2a interferon (IFN-alpha 2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-alpha 2a and cidofovir in inhibiting the proliferation of HPV-infected cells.

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