Expression Profiles of Two Types of Human Knee-joint Cartilage

Overview

Journal J Hum Genet

Specialty Genetics

Date 2003 May 6

PMID 12730720

Citations 12

Authors

Kensuke Ochi

Yataro Daigo

Toyomasa Katagiri

Akihiko Saito-Hisaminato

Tatsuhiko Tsunoda

Yoshiaki Toyama

Hideo Matsumoto

Yusuke Nakamura

Affiliations

Soon will be listed here.

Abstract

We have performed a comprehensive analysis of gene-expression profiles in human articular cartilage (hyaline cartilage) and meniscus (fibrocartilage) by means of a cDNA microarray consisting of 23,040 human genes. Comparing the profiles of the two types of cartilage with those of 29 other normal human tissues identified 24 genes that were specifically expressed in both cartilaginous tissues; these genes might be involved in maintaining phenotypes common to cartilage. We also compared the cartilage profiles with gene expression in human mesenchymal stem cells (hMSC), and detected 22 genes that were differentially expressed in cells representing the two cartilaginous lineages, 11 specific to each type, which could serve as markers for predicting the direction of chondrocyte differentiation. Our data should also provide useful information about regeneration of cartilage, especially in support of efforts to identify cartilage-specific molecules as potential agents for therapeutic approaches to joint repair.

Citing Articles

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Dai T, Pan Z, Yin F Orthop Surg. 2021; 13(8):2185-2195.

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Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar.

Rustenburg C, Emanuel K, Peeters M, Lems W, Vergroesen P, Smit T JOR Spine. 2019; 1(4):e1033.

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Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis.

Rai M, Tycksen E, Cai L, Yu J, Wright R, Brophy R Osteoarthritis Cartilage. 2019; 27(6):945-955.

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Meniscus, articular cartilage and nucleus pulposus: a comparative review of cartilage-like tissues in anatomy, development and function.

Chen S, Fu P, Wu H, Pei M Cell Tissue Res. 2017; 370(1):53-70.

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A Porcine Animal Model for Early Meniscal Degeneration - Analysis of Histology, Gene Expression and Magnetic Resonance Imaging Six Months after Resection of the Anterior Cruciate Ligament.

Kreinest M, Reisig G, Strobel P, Dinter D, Attenberger U, Lipp P PLoS One. 2016; 11(7):e0159331.

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