Analysis of Gene Expression in the Developing Mouse Retina

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2003 Apr 19

PMID 12702772

Citations 18

Authors

Elva Diaz

Yee Hwa Yang

Todd Ferreira

Kenneth C Loh

Yasushi Okazaki

Yoshihide Hayashizaki

Marc Tessier-Lavigne

Terence P Speed

John Ngai

Affiliations

Soon will be listed here.

Abstract

In the visual system, differential gene expression underlies development of the anterior-posterior and dorsal-ventral axes. Here we present the results of a microarray screen to identify genes differentially expressed in the developing retina. We assayed gene expression in nasal (anterior), temporal (posterior), dorsal, and ventral embryonic mouse retina. We used a statistical method to estimate gene expression between different retina regions. Genes were clustered according to their expression pattern and were ranked within each cluster. We identified groups of genes expressed in gradients or with restricted patterns of expression as verified by in situ hybridization. A common theme for the identified genes is the differential expression in the dorsal-ventral axis. By analyzing gene expression patterns, we provide insight into the molecular organization of the developing retina.

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