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Treatment of Ocular Inflammatory Disorders with Daclizumab

Overview
Journal Ophthalmology
Publisher Elsevier
Specialty Ophthalmology
Date 2003 Apr 12
PMID 12689903
Citations 29
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Abstract

Purpose: To evaluate the efficacy and safety of daclizumab therapy for patients with various ophthalmologic inflammatory disorders (all having previously failed standard treatment methods).

Design: Retrospective, nonrandomized case series.

Participants: Fourteen patients.

Methods: Fourteen patients were treated with daclizumab after previously failing standard treatment methods.

Main Outcome Measures: Inflammation and visual acuity.

Results: Twelve of 27 (44%) eyes and 5 of 14 (36%) patients had improvement in visual acuity; 9 of 27 (33%) eyes and 5 of 14 (36%) patients had no change in visual acuity; and 6 of 27 (22%) eyes and 4 of 14 (27%) patients had continued visual loss. Based on degree of inflammation, 16 of 27 eyes (59%) had improvement, 3 of 27 (11%) eyes had no change, and 8 of 27 (30%) eyes worsened.

Conclusions: Daclizumab is safe and, at least in some patients, appears to be an effective medication in the treatment of ocular inflammatory disorders.

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