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Pharmacotherapy for Uveitis: Current Management and Emerging Therapy

Overview
Journal Clin Ophthalmol
Publisher Dove Medical Press
Specialty Ophthalmology
Date 2014 Oct 7
PMID 25284976
Citations 32
Authors
Affiliations
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Abstract

Uveitis, a group of conditions characterized by intraocular inflammation, is a major cause of sight loss in the working population. Most uveitis seen in Western countries is noninfectious and appears to be autoimmune or autoinflammatory in nature, requiring treatment with immunosuppressive and/or anti-inflammatory drugs. In this educational review, we outline the ideal characteristics of drugs for uveitis and review the data to support the use of current and emerging therapies in this context. It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects.

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References
1.
Tian L, Yang P, Lei B, Shao J, Wang C, Xiang Q . AAV2-mediated subretinal gene transfer of hIFN-α attenuates experimental autoimmune uveoretinitis in mice. PLoS One. 2011; 6(5):e19542. PMC: 3096632. DOI: 10.1371/journal.pone.0019542. View

2.
Lubberts E, Koenders M, van den Berg W . The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther. 2005; 7(1):29-37. PMC: 1064899. DOI: 10.1186/ar1478. View

3.
Mandelcorn E . Infectious causes of posterior uveitis. Can J Ophthalmol. 2013; 48(1):31-9. DOI: 10.1016/j.jcjo.2012.11.013. View

4.
Reiff A, Takei S, Sadeghi S, Stout A, Shaham B, Bernstein B . Etanercept therapy in children with treatment-resistant uveitis. Arthritis Rheum. 2001; 44(6):1411-5. DOI: 10.1002/1529-0131(200106)44:6<1411::AID-ART235>3.0.CO;2-O. View

5.
Rosenfeld P, Brown D, Heier J, Boyer D, Kaiser P, Chung C . Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006; 355(14):1419-31. DOI: 10.1056/NEJMoa054481. View