Upstream Stimulatory Factors Are Mediators of Ca2+-responsive Transcription in Neurons

Overview

Journal J Neurosci

Specialty Neurology

Date 2003 Apr 10

PMID 12684442

Citations 62

Authors

Wen G Chen

Anne E West

Xu Tao

Gabriel Corfas

Marilyn N Szentirmay

Michele Sawadogo

Charles Vinson

Michael E Greenberg

Affiliations

Soon will be listed here.

Abstract

To identify molecular mechanisms that control activity-dependent gene expression in the CNS, we have characterized the factors that mediate activity-dependent transcription of BDNF promoter III. We report the identification of a Ca(2+)-responsive E-box element, CaRE2, within BDNF promoter III that binds upstream stimulatory factors 1 and 2 (USF1/2) and show that USFs are required for the activation of CaRE2-dependent transcription from BDNF promoter III. We find that the transcriptional activity of the USFs is regulated by Ca(2+)-activated signaling pathways in neurons and that the USFs bind to the promoters of a number of neuronal activity-regulated genes in vivo. These results suggest a new function for the USFs in the regulation of activity-dependent transcription in neurons.

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