FGFR1 is Independently Required in Both Developing Mid- and Hindbrain for Sustained Response to Isthmic Signals

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2003 Apr 19

PMID 12682014

Citations 91

Authors

Ras Trokovic

Nina Trokovic

Sanna Hernesniemi

Ulla Pirvola

Daniela M Vogt Weisenhorn

Janet Rossant

Andrew P McMahon

Wolfgang Wurst

Juha Partanen

Affiliations

Soon will be listed here.

Abstract

Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue-specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain-hindbrain and midbrain-specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border.

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