Continuous Growth of Mean Tumor Diameter in a Subset of Grade II Gliomas

Overview

Journal Ann Neurol

Specialty Neurology

Date 2003 Apr 1

PMID 12666121

Citations 150

Authors

Emmanuel Mandonnet

Jean-Yves Delattre

Marie-Laure Tanguy

Kristin R Swanson

Antoine F Carpentier

Hugues Duffau

Philippe Cornu

Remy van Effenterre

Ellsworth C Alvord Jr

Laurent Capelle

Affiliations

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Abstract

Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.

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