Comparative Genomics of Salmonella Enterica Serovar Typhi Strains Ty2 and CT18

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2003 Mar 20

PMID 12644504

Citations 168

Authors

Wen Deng

Shian-Ren Liou

Guy Plunkett 3rd

George F Mayhew

Debra J Rose

Valerie Burland

Voula Kodoyianni

David C Schwartz

Frederick R Blattner

Affiliations

Soon will be listed here.

Abstract

We present the 4.8-Mb complete genome sequence of Salmonella enterica serovar Typhi strain Ty2, a human-specific pathogen causing typhoid fever. A comparison with the genome sequence of recently isolated S. enterica serovar Typhi strain CT18 showed that 29 of the 4,646 predicted genes in Ty2 are unique to this strain, while 84 genes are unique to CT18. Both genomes contain more than 200 pseudogenes; 9 of these genes in CT18 are intact in Ty2, while 11 intact CT18 genes are pseudogenes in Ty2. A half-genome interreplichore inversion in Ty2 relative to CT18 was confirmed. The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics.

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