Bacterial [Cu,Zn]-cofactored Superoxide Dismutase Protects Opsonized, Encapsulated Neisseria Meningitidis from Phagocytosis by Human Monocytes/macrophages

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2003 Feb 22

PMID 12595487

Citations 16

Authors

Kate L R Dunn

Jayne L Farrant

Paul R Langford

J Simon Kroll

Affiliations

Soon will be listed here.

Abstract

Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.

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