Practical Aspects of Conducting Large-scale Functional Magnetic Resonance Imaging Studies in Children

Overview

Journal J Child Neurol

Specialties Neurology
Pediatrics

Date 2003 Feb 21

PMID 12593460

Citations 90

Authors

Anna Weber Byars

Scott K Holland

Richard H Strawsburg

Wendy Bommer

R Scott Dunn

Vince J Schmithorst

Elena Plante

Affiliations

Soon will be listed here.

Abstract

The potential benefits of functional magnetic resonance imaging (MRI) for the investigation of normal development have been limited by difficulties in its use with children. We describe the practical aspects, including failure rates, involved in conducting large-scale functional MRI studies with normal children. Two hundred and nine healthy children between the ages of 5 and 18 years participated in a functional MRI study of language development. Reliable activation maps were obtained across the age range. Younger children had significantly higher failure rates than older children and adolescents. It is concluded that it is feasible to conduct large-scale functional MRI studies of children as young as 5 years old. These findings can be used by other research groups to guide study design and plans for recruitment of young subjects.

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