Urinary Heat Shock Protein-72 Excretion in Clinical and Experimental Renal Ischemia

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2003 Feb 13

PMID 12579395

Citations 15

Authors

Thomas Mueller

Bettina Bidmon

Patrick Pichler

Klaus Arbeiter

Dagmar Ruffingshofer

Scott K VanWhy

Christoph Aufricht

Affiliations

Soon will be listed here.

Abstract

Renal ischemia not only causes injury but also induces repair mechanisms, such as the cellular induction of the 72-kilodalton heat shock protein HSP-72. The aim of this study was to determine whether HSP-72 is excreted in urine after ischemic renal injury. The first urine of six pediatric allograft recipients was examined for proteinuria and urinary HSP-72 excretion. Sprague-Dawley rats were treated with renal ischemia or hyperthermia and renal cortex and urinary HSP-72 levels were determined. HSP-72 was excreted in the first urine of renal allografts. In rats, renal HSP-72 was induced both by renal ischemia or hyperthermia. However, only renal ischemia resulted in urinary excretion of HSP-72. Urinary excretion of HSP-72 indicates an increased renal stress response and loss of tubular cell integrity after clinical and experimental renal ischemia.

Citing Articles

Extracellular HSPs: The Potential Target for Human Disease Therapy.

Li D, Liang S, Wen J, Tang J, Deng S, Liu Y Molecules. 2022; 27(7).

PMID: 35408755 PMC: 9000741. DOI: 10.3390/molecules27072361.

Renal biomarkers in cats: A review of the current status in chronic kidney disease.

Kongtasai T, Paepe D, Meyer E, Mortier F, Marynissen S, Stammeleer L J Vet Intern Med. 2022; 36(2):379-396.

PMID: 35218249 PMC: 8965260. DOI: 10.1111/jvim.16377.

Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature.

Thipsawat S Diab Vasc Dis Res. 2021; 18(6):14791641211058856.

PMID: 34791910 PMC: 8606936. DOI: 10.1177/14791641211058856.

Heat shock proteins and kidney disease: perspectives of HSP therapy.

Chebotareva N, Bobkova I, Shilov E Cell Stress Chaperones. 2017; 22(3):319-343.

PMID: 28409327 PMC: 5425374. DOI: 10.1007/s12192-017-0790-0.

The role of heat shock proteins in kidney disease.

Nayak Rao S J Transl Int Med. 2017; 4(3):114-117.

PMID: 28191532 PMC: 5290888. DOI: 10.1515/jtim-2016-0034.

References

Pockley A . Heat shock proteins, anti-heat shock protein reactivity and allograft rejection. Transplantation. 2001; 71(11):1503-7. DOI: 10.1097/00007890-200106150-00001. View

Emami A, Schwartz J, Borkan S . Transient ischemia or heat stress induces a cytoprotectant protein in rat kidney. Am J Physiol. 1991; 260(4 Pt 2):F479-85. DOI: 10.1152/ajprenal.1991.260.4.F479. View

Dodd S, Martin J, Swash M, Mather K . Expression of heat shock protein epitopes in renal disease. Clin Nephrol. 1993; 39(5):239-44. View

Li B, Hartono C, Ding R, Sharma V, Ramaswamy R, Qian B . Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med. 2001; 344(13):947-54. DOI: 10.1056/NEJM200103293441301. View

Morimoto R, Santoro M . Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol. 1998; 16(9):833-8. DOI: 10.1038/nbt0998-833. View

Alevy Y, Brennan D, Durriya S, Howard T, Mohanakumar T . Increased expression of the HDJ-2 heat shock protein in biopsies of human rejected kidney. Transplantation. 1996; 61(6):963-7. DOI: 10.1097/00007890-199603270-00020. View

Venkataseshan V, Marquet E . Heat shock protein 72/73 in normal and diseased kidneys. Nephron. 1996; 73(3):442-9. DOI: 10.1159/000189108. View

Aufricht C, Bidmon B, Ruffingshofer D, Regele H, Herkner K, Siegel N . Ischemic conditioning prevents Na,K-ATPase dissociation from the cytoskeletal cellular fraction after repeat renal ischemia in rats. Pediatr Res. 2002; 51(6):722-7. DOI: 10.1203/00006450-200206000-00010. View

Minowada G, Welch W . Clinical implications of the stress response. J Clin Invest. 1995; 95(1):3-12. PMC: 295356. DOI: 10.1172/JCI117655. View

10.

Rosen S, Heyman S . Difficulties in understanding human "acute tubular necrosis": limited data and flawed animal models. Kidney Int. 2001; 60(4):1220-4. DOI: 10.1046/j.1523-1755.2001.00930.x. View

11.

Perdrizet G, Shapiro D, Rewinski M . Surgical stress and the heat shock response: in vivo models of stress conditioning. Ann N Y Acad Sci. 1999; 874:320-5. DOI: 10.1111/j.1749-6632.1999.tb09247.x. View

12.

van Why S, Hildebrandt F, Ardito T, Mann A, Siegel N, Kashgarian M . Induction and intracellular localization of HSP-72 after renal ischemia. Am J Physiol. 1992; 263(5 Pt 2):F769-75. DOI: 10.1152/ajprenal.1992.263.5.F769. View

13.

Redaelli C, Wagner M, Kulli C, Tian Y, Kubulus D, Mazzucchelli L . Hyperthermia-induced HSP expression correlates with improved rat renal isograft viability and survival in kidneys harvested from non-heart-beating donors. Transpl Int. 2002; 14(6):351-60. DOI: 10.1007/s001470100000. View