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Role of Serine/threonine Protein Phosphatase in Alzheimer's Disease

Overview
Journal Neurosignals
Specialties Cell Biology
Neurology
Date 2003 Feb 5
PMID 12566927
Citations 57
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Abstract

Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer's disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on tau protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future.

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