The Regulatory Role of Valpha14 NKT Cells in Innate and Acquired Immune Response

Overview

Journal Annu Rev Immunol

Specialty Allergy & Immunology

Date 2003 Jan 25

PMID 12543936

Citations 254

Authors

Masaru Taniguchi

Michishige Harada

Satoshi Kojo

Toshinori Nakayama

Hiroshi Wakao

Affiliations

Soon will be listed here.

Abstract

A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.

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